Akio Masuda Selected Research

Meclizine (Meclozine)

12/2022	Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice.
2/2015	Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene.
1/2013	Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia.

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Akio Masuda Research Topics

Disease

8	Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital) 01/2021 - 12/2008
5	Parkinson Disease (Parkinson's Disease) 01/2021 - 04/2009
5	Osteoarthritis 02/2020 - 01/2014
4	Myotonic Dystrophy (Dystrophia Myotonica) 01/2020 - 01/2012
4	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2016 - 01/2013
4	Inflammation (Inflammations) 11/2010 - 10/2002
3	Motion Sickness (Airsickness) 12/2022 - 01/2013
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020 - 01/2013
2	Neoplasms (Cancer) 02/2019 - 02/2015
2	Stomach Neoplasms (Stomach Cancer) 02/2019 - 10/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2017 - 01/2016
2	Chondrosarcoma 01/2017 - 01/2013
2	Sarcoma (Soft Tissue Sarcoma) 01/2016 - 05/2015
2	Achondroplasia 02/2015 - 01/2013
2	Endplate Acetylcholinesterase Deficiency 07/2013 - 08/2009
2	Hypersensitivity (Allergy) 11/2009 - 01/2007
2	Infections 09/2004 - 08/2004
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 12/2022
1	Body Weight (Weight, Body) 12/2022
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2021
1	Neuralgia (Stump Neuralgia) 12/2020
1	Pain (Aches) 12/2020
1	Epilepsy (Aura) 01/2020
1	Spinal Cord Diseases 01/2020
1	Neoplasm Metastasis (Metastasis) 02/2019
1	Disseminated Intravascular Coagulation 10/2017
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2016
1	Carcinogenesis 01/2016
1	Femoral Fractures (Femoral Fracture) 12/2015
1	Myasthenia Gravis 09/2015
1	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 08/2015
1	Myotonia 08/2015
1	Breast Neoplasms (Breast Cancer) 02/2015
1	Peripheral Nerve Injuries 01/2015
1	Heterotopic Ossification (Ectopic Ossification) 01/2013
1	Thanatophoric Dysplasia (Dwarfism, Thanatophoric) 01/2013
1	Osteogenesis Imperfecta (Lobstein Disease) 11/2011
1	Muscular Diseases (Myopathy) 08/2009
1	Fibrosarcoma 09/2004

Drug/Important Bio-Agent (IBA)

7	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2020 - 01/2012
7	RNA (Ribonucleic Acid)IBA 01/2016 - 01/2012
5	Pharmaceutical PreparationsIBA 12/2022 - 01/2013
5	CytokinesIBA 12/2020 - 10/2002
5	CateninsIBA 02/2020 - 01/2014
4	Zonisamide (Zonegran)FDA LinkGeneric 01/2021 - 01/2015
3	Meclizine (Meclozine)FDA LinkGeneric 12/2022 - 01/2013
3	muskIBA 09/2015 - 07/2013
3	Heterogeneous-Nuclear Ribonucleoprotein Group F-HIBA 08/2015 - 12/2008
3	Proteins (Proteins, Gene)FDA Link 02/2015 - 08/2004
2	Histamine (Histamine Dihydrochloride)FDA Link 12/2022 - 01/2013
2	Cholinergic ReceptorsIBA 01/2021 - 09/2015
2	Antidepressive Agents (Antidepressants)IBA 12/2020 - 01/2017
2	MianserinIBA 02/2020 - 01/2019
2	Carrier Proteins (Binding Protein)IBA 01/2020 - 09/2004
2	CalciumIBA 10/2017 - 08/2009
2	AgrinIBA 09/2015 - 04/2014
2	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 02/2015 - 01/2013
2	Interleukin-10 (Interleukin 10)IBA 11/2010 - 08/2004
2	Interleukin-13IBA 11/2010 - 11/2004
2	HydrogenIBA 11/2009 - 04/2009
2	Interleukin-12 (IL 12)IBA 09/2004 - 08/2004
1	Nonsense Codon (Nonsense Mutation)IBA 12/2022
1	DystrophinIBA 12/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 12/2020
1	Local AnestheticsIBA 12/2020
1	Small Nuclear Ribonucleoproteins (snRNP)IBA 01/2020
1	Nuclear RNAIBA 01/2020
1	NivolumabIBA 02/2019
1	Dacarbazine (DIC)FDA LinkGeneric 10/2017
1	Fluorouracil (Carac)FDA LinkGeneric 10/2017
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2017
1	Fluoxetine (Prozac)FDA LinkGeneric 01/2017
1	3' Untranslated Regions (3' UTR)IBA 01/2016
1	RNA-Binding Protein FUSIBA 01/2016
1	Phenylbutazone (Butazolidin)FDA Link 01/2016
1	Lansoprazole (Prevacid)FDA LinkGeneric 12/2015
1	Immunoglobulin G (IgG)IBA 09/2015
1	AntibodiesIBA 09/2015
1	perlecanIBA 08/2015
1	Nonprescription Drugs (Patent Medicines)IBA 02/2015
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2015
1	Verapamil (Calan)FDA LinkGeneric 01/2014
1	NucleotidesIBA 10/2013
1	PerhexilineIBA 01/2013
1	FendilineIBA 01/2013
1	alpha2 Subunit Collagen Type IIBA 11/2011
1	Interleukin-5 (Interleukin 5)IBA 11/2010
1	Interleukin-6 (Interleukin 6)IBA 11/2010
1	AcetylcholinesteraseIBA 08/2009
1	CollagenIBA 08/2009
1	Drinking WaterIBA 04/2009
1	Tannic Acid FDA Link 04/2009
1	Polypyrimidine Tract-Binding ProteinIBA 04/2009
1	Immunoglobulin E (IgE)IBA 01/2007
1	AntigensIBA 09/2004
1	Messenger RNA (mRNA)IBA 09/2004

Therapy/Procedure

2	Therapeutics 02/2019 - 01/2013
2	Drug Therapy (Chemotherapy) 02/2019 - 10/2017
1	Immunotherapy 02/2019
1	Surgical Instruments (Clip) 05/2015